Publication: Antihyperuricemic activity of Euphorbia hirta (Tawa-tawa) leaf extract in mice
No Thumbnail Available
Date
2016-03
Journal Title
Journal ISSN
Volume Title
Publisher
Don Mariano Marcos Memorial State University - South La Union Campus
Abstract
Gout has become a common disease at present. Despite the many commercially
available drugs, most of these cause side -effects. Hence, in search for potential
antihyperuricemic agent, this study has been conducted.
Potassium oxonate was introduced to male albino mice to produce a
hyperuricemic model. Different treatments were administered to the hyperuricemic mice
namely distilled water, allopurinol and different concentrations of Euphorbia hirta leaf
extract to assess their antihyperuricemic activity in terms of % inhibition.
The phytochemicals detected in E. hirta leaves were flavonoids which may be
responsible in inhibiting the enzyme xanthine oxidase. There were also saponins,
phenolics, carbohydrates, reducing sugars and proteins present. The findings showed
that 7.5, 15, 30 mg E. hirta/Stl g bw of mouse significantly affected the SUA levels of the
mice. In addition, the plant extract acts in dose-dependent manner suggesting that E.
hirta leaf extract can be a good candidate agent against hyperuricemia.
Description
Full text.
Keywords
Citation
Dulay, E. C. G., De Guzman, E. V., Estoesta, E. M. C., & Lagliva, R. N. O. (2016) Antihyperuricemic activity of Euphorbia hirta (Tawa-tawa) leaf extract in mice [Unpublished Undergraduate thesis]. Don Mariano Marcos Memorial State University - South La Union Campus, Agoo, La Union.