Angio-suppressive and non-teratogenic properties of morus alba l. (Mulberry) fruit extract using chorioallantoic membranes and embryos of anas platyrhynchos (Duck)
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2020-06
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Don Mariano Marcos Memorial State University - South La Union Campus
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Chronic diseases such as cancer remains as a threat to humanity, thus researchers continue to explore plants’ potential bioactivities to combat them. This study tested the angio-suppressive and non-teratogenic properties of varying concentrations of Morus alba L. fruit ethanolic extract (MFEE) on chorioallantoic membranes and embryos of Anas platyrhynchos. Phytochemical screening of mulberry fruit was conducted and validated the presence of alkaloids, phenolics, flavonoids, carbohydrates and reducing sugars. 4 possible inhibition of neovascularization was indicated by the considerable reduction in number of branches per segment and branch point density, and increased intercapillary distance in CAMs exposed to 60-75ug/ml M. alba fruit extract. Vascular occlusions and petechial hemorrhage were also recorded in all MFEE-treated CAMs. Apparent non-teratogenicity of the extract was revealed by the increase in body weight, beak length, forelimb length, hindlimb length, body length in embryos administered with 15-30ug/ml M. alba fruit extract. All MFEE-treated embryos did not show any physical deformities or malformations, and normal cartilage formation was also recorded.
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Barrameda, E.M. (2020). Angio-suppressive and non-teratogenic properties of morus alba l. (Mulberry) fruit extract using chorioallantoic membranes and embryos of anas platyrhynchos (Duck). [Unpublished Master's Thesis]. Don Mariano Marcos Memorial State University – South La Union Campus, Agoo, La Union. Lakasa ti Sirib, DMMMSU Institutional Repository.
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